Microglial K(+) channel expression in young adult and aged mice.

The K(+) channel expression pattern of microglia strongly depends on the cells' microenvironment and has been recognized as a sensitive marker of the cells' functional state. While numerous studies have been performed on microglia in vitro, our knowledge about microglial K(+) channels and their regulation in vivo is limited. Here, we have investigated K(+) currents of microglia in striatum, neocortex and entorhinal cortex of young adult and aged mice. Although almost all microglial cells exhibited inward rectifier K(+) currents upon membrane hyperpolarization, their mean current density was significantly enhanced in aged mice compared with that determined in young adult mice. Some microglial cells additionally exhibited outward rectifier K(+) currents in response to depolarizing voltage pulses. In aged mice, microglial outward rectifier K(+) current density was significantly larger than in young adult mice due to the increased number of aged microglial cells expressing these channels. Aged dystrophic microglia exhibited outward rectifier K(+) currents more frequently than aged ramified microglia. The majority of microglial cells expressed functional BK-type, but not IK- or SK-type, Ca(2+) -activated K(+) channels, while no differences were found in their expression levels between microglia of young adult and aged mice. Neither microglial K(+) channel pattern nor K(+) channel expression levels differed markedly between the three brain regions investigated. It is concluded that age-related changes in microglial phenotype are accompanied by changes in the expression of microglial voltage-activated, but not Ca(2+) -activated, K(+) channels

Space shuttle: Static aerodynamic and control investigation of an expendable second stage with payload alone and with delta wing booster (B-15B-1)

Aerodynamic force and moment coefficients for scale model of expendable second stage modified S-2 alone and mounted piggyback on space shuttle booster from Mach 0.6 to 4.9

Space shuttle: Static stability and control investigation of NR/GD delta wing booster (B-20) and delta wing orbiter (134D), volume 1

Experimental aerodynamic investigations have been made on a .0035 scale model North American Rockwell/General Dynamics version of the space shuttle. Static stability and control data were obtained on the delta wing booster alone (B-20) and with the delta wing orbiter (134D) mounted in various positions on the booster. Six component aerodynamic force and moment data were recorded over an angle of attack range from -10 deg to 24 deg at 0 deg and 6 deg sideslip angles and from -10 deg to +10 deg sideslip at 0 deg angle of attack. Mach number ranged from 0.6 to 4.96

Inverse photoemission in strongly correlated electron systems

Based on exact results for small clusters of 2D t-J model we demonstrate the existence of several distinct `channels' in its inverse photoemission (IPES) spectrum. Hole-like quasiparticles can either be annihilated completely, or leave behind a variable number of spin excitations, which formed the `dressing cloud' of the annihilated hole. In the physical parameter regime the latter processes carry the bulk of IPES weight and although the Fermi surface takes the form of hole pockets, the distribution of spectal weight including these `magnon-bands' in the IPES spectrum is reminiscent of free electrons. The emerging scenario for Fermiology and spectral weight distribution is shown to be consistent with photoemission, inverse photemission and de Haas--van Alphen experiments on cuprate superconductors.Comment: Revtex file, 4 PRB pages + three figures appended as uu-encoded postscript. Hardcopies of figures (or the entire manuscript) can also be obtained by e-mail request to: [email protected]